Mutations in LCDs can promote irreversible amyloid aggregation and disease. In other words, a one night stand turned very complicated.Proteins including FUS, hnRNPA2, and TDP-43 reversibly aggregate into amyloid-like fibrils through interactions of their low-complexity domains (LCDs). The consequences come knocking on her door days later, the moment she’s introduced to her new intern. Letting loose has never been Cordelia’s forte, but when she meets a wild haired beauty during a night out, a one night stand might just be on the table.
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